{"id":446,"date":"2025-11-24T09:56:28","date_gmt":"2025-11-24T09:56:28","guid":{"rendered":"https:\/\/info.ias.tuwien.ac.at\/bsc\/?page_id=446"},"modified":"2025-11-26T13:31:56","modified_gmt":"2025-11-26T13:31:56","slug":"rudroff-lab","status":"publish","type":"page","link":"https:\/\/info.ias.tuwien.ac.at\/bsc\/rudroff-lab\/","title":{"rendered":"Rudroff Lab"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"446\" class=\"elementor elementor-446\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-668ec27 e-con-full e-flex e-con e-parent\" data-id=\"668ec27\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-fa80375 e-con-full elementor-hidden-tablet elementor-hidden-mobile e-flex e-con e-child\" data-id=\"fa80375\" data-element_type=\"container\" 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data-widget_type=\"nested-tabs.default\">\n\t\t\t\t\t\t\t<div class=\"e-n-tabs\" data-widget-number=\"62479313\" aria-label=\"Tabs. Open items with Enter or Space, close with Escape and navigate using the Arrow keys.\">\n\t\t\t<div class=\"e-n-tabs-heading\" role=\"tablist\">\n\t\t\t\t\t<button id=\"e-n-tab-title-624793131\" class=\"e-n-tab-title\" aria-selected=\"true\" data-tab-index=\"1\" role=\"tab\" tabindex=\"0\" aria-controls=\"e-n-tab-content-624793131\" style=\"--n-tabs-title-order: 1;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\tResearch\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t<button id=\"e-n-tab-title-624793132\" class=\"e-n-tab-title\" aria-selected=\"false\" data-tab-index=\"2\" role=\"tab\" tabindex=\"-1\" aria-controls=\"e-n-tab-content-624793132\" style=\"--n-tabs-title-order: 2;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\tCV\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t<button id=\"e-n-tab-title-624793133\" class=\"e-n-tab-title\" aria-selected=\"false\" data-tab-index=\"3\" role=\"tab\" tabindex=\"-1\" aria-controls=\"e-n-tab-content-624793133\" style=\"--n-tabs-title-order: 3;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\tMembers\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t<button id=\"e-n-tab-title-624793134\" class=\"e-n-tab-title\" aria-selected=\"false\" data-tab-index=\"4\" role=\"tab\" tabindex=\"-1\" aria-controls=\"e-n-tab-content-624793134\" style=\"--n-tabs-title-order: 4;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\tProjects\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t<button id=\"e-n-tab-title-624793135\" class=\"e-n-tab-title\" aria-selected=\"false\" data-tab-index=\"5\" role=\"tab\" tabindex=\"-1\" aria-controls=\"e-n-tab-content-624793135\" style=\"--n-tabs-title-order: 5;\">\n\t\t\t\t\t\t<span class=\"e-n-tab-title-text\">\n\t\t\t\tPublications\t\t\t<\/span>\n\t\t<\/button>\n\t\t\t\t\t<\/div>\n\t\t\t<div class=\"e-n-tabs-content\">\n\t\t\t\t<div id=\"e-n-tab-content-624793131\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-624793131\" data-tab-index=\"1\" style=\"--n-tabs-title-order: 1;\" class=\"e-active elementor-element elementor-element-c802cdb e-con-full e-flex e-con e-child\" data-id=\"c802cdb\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-808546e e-con-full e-flex e-con e-child\" data-id=\"808546e\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ed267b4 elementor-widget elementor-widget-heading\" data-id=\"ed267b4\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Current research:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6b064e0 elementor-widget elementor-widget-text-editor\" data-id=\"6b064e0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Prof. Rudroff\u2019s research combines biocatalysis, synthetic organic chemistry, metabolic engineering, and systems biotechnology to design artificial multistep catalytic cascades in living organisms. His group investigates the interface of chemo- and biocatalysis, using retrosynthetic logic to construct de novo pathways composed of enzymes, organocatalysts, and metal catalysts. These \u201cmini pathways\u201d are introduced into heterologous hosts or examined in vitro to enable novel transformations, including the synthesis of fine chemicals, polyhydroxylated compounds, and natural fragrance and flavour molecules. His group has recently expanded into photobiocatalysis, exploring flavin activation under light and employing cyanobacteria as fully sustainable phototrophic chassis capable of using only CO\u2082, light, and inorganic nutrients for whole-cell catalysis. Additional research focuses include high-throughput droplet-based screening (FADS), enzyme redesign and stabilization, and light-driven oxidation strategies.<\/p><p><b>Research topics in a nutshell:<\/b><\/p><ul><li>Development of novel artificial enzyme cascades in E. coli and cyanobacteria.<\/li><li>Creation of high-throughput functional assays for enzyme evolution.<\/li><li>Application of photobiocatalytic strategies employing flavin activation under light.<\/li><li>Biocatalytic production of fragrance aldehydes and pyrazine derivatives.<\/li><li>New concepts for polyolefin degradation using light, oxygen, and photosensitizing proteins (doctoral project topics).<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e0a512f elementor-widget elementor-widget-image\" data-id=\"e0a512f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"2560\" height=\"809\" src=\"https:\/\/info.ias.tuwien.ac.at\/bsc\/wp-content\/uploads\/sites\/2\/2025\/11\/Research-Key-Figure-HP_new-scaled.png\" class=\"attachment-full size-full wp-image-972\" alt=\"\" srcset=\"https:\/\/info.ias.tuwien.ac.at\/bsc\/wp-content\/uploads\/sites\/2\/2025\/11\/Research-Key-Figure-HP_new-scaled.png 2560w, https:\/\/info.ias.tuwien.ac.at\/bsc\/wp-content\/uploads\/sites\/2\/2025\/11\/Research-Key-Figure-HP_new-300x95.png 300w, https:\/\/info.ias.tuwien.ac.at\/bsc\/wp-content\/uploads\/sites\/2\/2025\/11\/Research-Key-Figure-HP_new-1024x324.png 1024w, https:\/\/info.ias.tuwien.ac.at\/bsc\/wp-content\/uploads\/sites\/2\/2025\/11\/Research-Key-Figure-HP_new-768x243.png 768w, https:\/\/info.ias.tuwien.ac.at\/bsc\/wp-content\/uploads\/sites\/2\/2025\/11\/Research-Key-Figure-HP_new-1536x485.png 1536w, https:\/\/info.ias.tuwien.ac.at\/bsc\/wp-content\/uploads\/sites\/2\/2025\/11\/Research-Key-Figure-HP_new-2048x647.png 2048w\" sizes=\"(max-width: 2560px) 100vw, 2560px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-624793132\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-624793132\" data-tab-index=\"2\" style=\"--n-tabs-title-order: 2;\" class=\" elementor-element elementor-element-8ee58a6 e-con-full e-flex e-con e-child\" data-id=\"8ee58a6\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-6284e44 e-con-full e-flex e-con e-child\" data-id=\"6284e44\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2632853 elementor-widget elementor-widget-text-editor\" data-id=\"2632853\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Florian Rudroff, born in Vienna, studied Technical Chemistry, with specialization in Organic Chemistry at the TU Wien. He conducted his diploma and PhD thesis in the group of Prof. Marko Mihovilovic and obtained his PhD in 2007 from TU Wien. The topic of the PhD thesis was located at the interface between Biology and Chemistry in the field of Biocatalysis. Afterwards he was awarded with an \u2019Erwin Schr\u00f6dinger fellowship\u2019 and went for a postdoctoral stay to the group of Prof. Uwe Sauer at ETH Zurich. His research was mainly conducted to Molecular Systems Biology (metabolomics and fluxomics) and specifically to the rapid metabolic and TOR signalling responses in Saccharomyces cerevisiae upon different nitrogen input signals.<\/p><p>In 2011, he returned to the TU Wien and started his independent scientific career in the field of Systems Biocatalysis. Since December 2017, he became Assistant Professor and finished his Habilitation in the field of Bioorganic Chemistry at the Institute of Applied Synthetic Chemistry, TU Wien. In 2020, he was appointed as Assoc. Professor and group leader of the Bioorganic Synthetic Chemistry Group (BSC) at the TU Wien. Since 2018 he is leader of the local branch (Vienna, lower Austria, Burgenland) of the Austrian Chemical Society (G\u00d6CH).<\/p><p>His main research interests are located in the field of enzyme cascade catalysis, photoredox biocatalysis (e.g, CO<sub>2\u00a0<\/sub>utilization by cyanobacteria), protein engineering, the development of high throughput platforms (e.g. fluorescence adsorption droplet sorting, FADS) and organic synthesis.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-624793133\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-624793133\" data-tab-index=\"3\" style=\"--n-tabs-title-order: 3;\" class=\" elementor-element elementor-element-7e1c787 e-con-full e-flex e-con e-child\" data-id=\"7e1c787\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-527f18d e-con-full e-flex e-con e-child\" data-id=\"527f18d\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9a61b33 elementor-widget__width-inherit elementor-widget elementor-widget-image\" data-id=\"9a61b33\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1920\" height=\"1281\" src=\"https:\/\/info.ias.tuwien.ac.at\/bsc\/wp-content\/uploads\/sites\/2\/2025\/11\/Bios.jpg\" class=\"attachment-full size-full wp-image-412\" alt=\"\" srcset=\"https:\/\/info.ias.tuwien.ac.at\/bsc\/wp-content\/uploads\/sites\/2\/2025\/11\/Bios.jpg 1920w, https:\/\/info.ias.tuwien.ac.at\/bsc\/wp-content\/uploads\/sites\/2\/2025\/11\/Bios-300x200.jpg 300w, https:\/\/info.ias.tuwien.ac.at\/bsc\/wp-content\/uploads\/sites\/2\/2025\/11\/Bios-1024x683.jpg 1024w, https:\/\/info.ias.tuwien.ac.at\/bsc\/wp-content\/uploads\/sites\/2\/2025\/11\/Bios-768x512.jpg 768w, https:\/\/info.ias.tuwien.ac.at\/bsc\/wp-content\/uploads\/sites\/2\/2025\/11\/Bios-1536x1025.jpg 1536w\" sizes=\"(max-width: 1920px) 100vw, 1920px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-624793134\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-624793134\" data-tab-index=\"4\" style=\"--n-tabs-title-order: 4;\" class=\" elementor-element elementor-element-ac8aaf7 e-flex e-con-boxed e-con e-child\" data-id=\"ac8aaf7\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-77297e4 elementor-widget elementor-widget-n-accordion\" data-id=\"77297e4\" data-element_type=\"widget\" data-settings=\"{&quot;default_state&quot;:&quot;expanded&quot;,&quot;max_items_expended&quot;:&quot;one&quot;,&quot;n_accordion_animation_duration&quot;:{&quot;unit&quot;:&quot;ms&quot;,&quot;size&quot;:400,&quot;sizes&quot;:[]}}\" data-widget_type=\"nested-accordion.default\">\n\t\t\t\t\t\t\t<div class=\"e-n-accordion\" aria-label=\"Accordion. Open links with Enter or Space, close with Escape, and navigate with Arrow Keys\">\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-1240\" class=\"e-n-accordion-item\" open>\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"1\" tabindex=\"0\" aria-expanded=\"true\" aria-controls=\"e-n-accordion-item-1240\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> GreenChemForCE <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-minus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h384c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t\t<span class='e-closed'><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-plus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1240\" class=\"elementor-element elementor-element-9921872 e-con-full e-flex e-con e-child\" data-id=\"9921872\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b494bab elementor-widget elementor-widget-heading\" data-id=\"b494bab\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">GreenChemForCE<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b17d445 elementor-widget elementor-widget-text-editor\" data-id=\"b17d445\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Project official webpage:\u00a0<a href=\"https:\/\/www.interreg-central.eu\/projects\/greenchemforce\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.interreg-central.eu\/projects\/greenchemforce\/<\/a><br \/>Project description:<\/p><ul><li><strong>Challenge<\/strong>: Unsustainable chemical industry practices and poor public perception in Central Europe.<\/li><li><strong>Objective<\/strong>: Reduce environmental impact and revitalize the local chemical sector.<\/li><li><strong>Innovation<\/strong>: Implement advanced, sustainable, and circular economy processes.<\/li><li><strong>Outputs<\/strong>: Green production methods, industry training, and public awareness initiatives.<\/li><li><strong>Approach<\/strong>: Transnational collaboration across academia and industry.<\/li><li><strong>Cooperation<\/strong>: Shared expertise fosters sustainable regional improvements.<\/li><li><strong>Vision<\/strong>: Return of chemical production to Europe with eco-friendly practices.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-1241\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"2\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-1241\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Circular Bioengineering <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-minus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h384c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t\t<span class='e-closed'><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-plus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1241\" class=\"elementor-element elementor-element-11c8d1f e-con-full e-flex e-con e-child\" data-id=\"11c8d1f\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-00a7201 elementor-widget elementor-widget-heading\" data-id=\"00a7201\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Circular Bioengineering \u2013 Powering the Circular Bioeconomy<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4914cb5 elementor-widget elementor-widget-text-editor\" data-id=\"4914cb5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Project Website:\u00a0<a href=\"https:\/\/www.circularbioengineering.at\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.circularbioengineering.at\/<\/a><br \/>Project description:<\/p><ul><li><strong>Objective<\/strong>: Revolutionize production and life cycles of goods through bio-based materials and zero-waste processes.<\/li><li><strong>Approach<\/strong>: Cross-disciplinary research combining molecular biosciences, biotechnology, and bioprocess assessment.<\/li><li><strong>Innovation<\/strong>: Develop technology-integrated biosystems (e.g., enzymes, cells) for sustainable, low-energy, and eco-friendly production.<\/li><li><strong>Sustainability<\/strong>: Focus on bioeconomy principles\u2014minimal substance and energy use, zero waste, and environmental consideration.<\/li><li><strong>Impact<\/strong>: Train future scientists, engage stakeholders, and foster public awareness to advance the bioeconomy.<\/li><li><strong>Collaboration<\/strong>: Supported by five partner universities led by BOKU University, alongside the universities of Graz, Vienna, and their technical counterparts.<\/li><li><strong>Outreach<\/strong>: Serve the scientific community and stakeholders through research, education, and dissemination activities.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-1242\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"3\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-1242\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Pyrazine synthesis <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-minus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h384c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t\t<span class='e-closed'><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-plus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1242\" class=\"elementor-element elementor-element-4619df9 e-con-full e-flex e-con e-child\" data-id=\"4619df9\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7beaa1b elementor-widget elementor-widget-heading\" data-id=\"7beaa1b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Pyrazine synthesis \u2013 A greener way for our daily flavor and smell<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-91f0394 elementor-widget elementor-widget-text-editor\" data-id=\"91f0394\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Project description:<\/p><ul><li>Biocatalytic retrosynthesis for the production of heterocycles<\/li><li>Biocatalytic synthesis of flavour and fragrance compounds via different enzymatic cascades<\/li><li>Comparison of chemical &amp; enzymatic routes<\/li><li>FADS-based (fluorscence activated droplet sorting) enzyme-assay development<\/li><li>Biomimicking of chemical flavour production starting from sugar beet molasses<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-1243\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"4\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-1243\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> BioZone <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-minus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h384c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t\t<span class='e-closed'><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-plus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1243\" class=\"elementor-element elementor-element-e03ee1d e-flex e-con-boxed e-con e-child\" data-id=\"e03ee1d\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-dae1fa8 elementor-widget elementor-widget-heading\" data-id=\"dae1fa8\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\nBioinspired alkene cleavage \u2013 BioZone<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fc52f0c elementor-widget elementor-widget-text-editor\" data-id=\"fc52f0c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The aim of this project is to develop a biological (enzyme-assisted) method for splitting carbon \/ carbon double bonds without the use of the dangerous \u2018ozone\u2019. The so-called ozonolysis is a widely used method for the production of so-called \u201ccarbonyl compounds\u201d. Such carbon \/ carbon double bond containing compounds can be starting materials to make such as flavor compounds like vanillin or fragrances like Lilial. Ozonolyis is mainly used on a laboratory scale. The reason for this is the toxicity of ozone and the danger of the intermediate products, which are not safe: Some of them have already caused industrial reactors to explode. We want to find and investigate a safe alternative with enzymes that can split C = C double bonds at room temperature, in water and by means of oxygen. We use a high-throughput detection method that is specifically designed for the detection of aldehydes (carbonyl compounds) in order to examine different protein sequences for their ability to split C = C double bonds. This detection method is highly sensitive, completely independent of structure, easy to use and extremely specific for aldehydes. With this detection method in combination with a special technique, it is possible to examine up to a million protein sequences in a day. It is thus possible to examine known enzymes for their substrate diversity and new enzymes for their activity in a very short time, as quantitatively as possible. After suitable enzymes have been found, we will use them for the production of potential new active pharmaceutical ingredients or flavorings.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-1244\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"5\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-1244\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Cyanobacteria <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-minus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h384c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t\t<span class='e-closed'><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-plus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1244\" class=\"elementor-element elementor-element-0e2b646 e-flex e-con-boxed e-con e-child\" data-id=\"0e2b646\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b4b1161 elementor-widget elementor-widget-heading\" data-id=\"b4b1161\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Cyanobacteria \u2013 Photo-Biocatalysis goes green and blue<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-094554b elementor-widget elementor-widget-text-editor\" data-id=\"094554b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Recently, several studies have proven the potential of cyanobacteria as whole-cell biocatalysts for biotransformations. Compared to heterotrophic hosts, cyanobacteria show unique advantages thanks to their photoautotrophic metabolism. Their ability to use light as energy and CO<sub>2<\/sub>\u00a0as carbon source promises a truly sustainable production platform. Moreover, their photoautotrophic metabolism offers an encouraging source of reducing power, which makes them attractive for redox-based biotechnological purposes. To exploit the full potential of these whole-cell biocatalysts, cyanobacterial cells must be considered in their entirety.<\/p><p>\u00a0<\/p><p>Project description:<\/p><ul><li>Expression of redox enzymes in cyanobacteria<\/li><li>Comparison of different cyanobacteria<\/li><li>Biocatalysis\u00a0 \u2013 single step and in a cascade fashion<\/li><li>Systems biology of cyanobacteria<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-1245\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"6\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-1245\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Enzyme cascades &amp; Chemo\/Biocatalysis <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-minus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h384c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t\t<span class='e-closed'><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-plus\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\"><\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1245\" class=\"elementor-element elementor-element-a078e95 e-flex e-con-boxed e-con e-child\" data-id=\"a078e95\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9c4f373 elementor-widget elementor-widget-heading\" data-id=\"9c4f373\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Enzyme cascades &amp; Chemo\/Biocatalysis<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b9a55b6 elementor-widget elementor-widget-text-editor\" data-id=\"b9a55b6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Project description:<\/p><ul><li>Development of novel strategies for the synthesis of high-value compounds by retrosynthesis<\/li><li>Combination of chemo and biocatalysis<\/li><li>Multi-step catalysis in vivo &amp; in vitro<\/li><li>Flux optimization \u2013 on transcriptional and translational level<\/li><li>Protein engineering<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div id=\"e-n-tab-content-624793135\" role=\"tabpanel\" aria-labelledby=\"e-n-tab-title-624793135\" data-tab-index=\"5\" style=\"--n-tabs-title-order: 5;\" class=\" elementor-element elementor-element-01c06c2 e-flex e-con-boxed e-con e-child\" data-id=\"01c06c2\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-9f6c419 e-con-full e-flex e-con e-child\" data-id=\"9f6c419\" data-element_type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7ab7ff4 e-con-full e-flex e-con e-child\" data-id=\"7ab7ff4\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b9f427b elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"b9f427b\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/info.ias.tuwien.ac.at\/bsc\/wp-content\/uploads\/sites\/2\/2025\/11\/Rudroff-square-profile-300.jpg\" class=\"attachment-full size-full wp-image-264\" alt=\"\" srcset=\"https:\/\/info.ias.tuwien.ac.at\/bsc\/wp-content\/uploads\/sites\/2\/2025\/11\/Rudroff-square-profile-300.jpg 300w, https:\/\/info.ias.tuwien.ac.at\/bsc\/wp-content\/uploads\/sites\/2\/2025\/11\/Rudroff-square-profile-300-150x150.jpg 150w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Florian Rudroff <\/h3><p class=\"elementor-image-box-description\">Univ.Prof. Dipl.-Ing. Dr.techn.<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1deed0b elementor-position-left elementor-vertical-align-middle elementor-widget elementor-widget-image-box\" data-id=\"1deed0b\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/info.ias.tuwien.ac.at\/bsc\/wp-content\/uploads\/sites\/2\/2025\/11\/Rudrofflab-logo-tile-150x150-1.png\" class=\"attachment-full size-full wp-image-419\" alt=\"\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Connect<\/h3><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-56afb5e elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"56afb5e\" 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[&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_acf_changed":false,"site-sidebar-layout":"no-sidebar","site-content-layout":"","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"disabled","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center 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