News and Updates

Chemo-Enzymatic Cascade for the Generation of Fragrance Aldehydes

Publication Title: Chemo-Enzymatic Cascade for the Generation of Fragrance Aldehydes by Daniel Schwendenwein, Anna K. Ressmann, Marcello Entner, Viktor Savic, Margit Winkler,* and Florian Rudroff* Catalysts 2021, 11(8), 932; Abstract In this study, we present the synthesis of chiral fragrance aldehydes, which was tackled by a combination of chemo-catalysis and a multi-enzymatic in vivo cascade reaction and

Continue Reading »

Enzyme Cascade Design and Modelling

In our book “Enzyme Cascade Design and Modelling” we have joined our forces and brought a team of experts in multi-enzymatic and chemo-enzymatic cascades! Editors: Kara, Selin, Rudroff, Florian (Eds.) Book Highlights Creates the basis for pathway design via the concept of ‘biocatalytic retrosynthesis’ Enhances the readers’ understanding on kinetic modelling and reaction engineering Introduces process design,

Continue Reading »

Cell‐free in vitro reduction of carboxylates to aldehydes: With crude enzyme preparations to a key pharmaceutical building block

The scarcity of practical methods for aldehyde synthesis in chemistry necessitates the development of mild, selective procedures. Carboxylic acid reductases catalyze aldehyde formation from stable carboxylic acid precursors in an aqueous solution. Carboxylic acid reductases were employed to catalyze aldehyde formation in a cell‐free system with activation energy and reducing equivalents provided through auxiliary proteins

Continue Reading »

Biocatalysis in Green and Blue: Cyanobacteria

Recently, several studies have proven the potential of cyanobacteria as whole-cell biocatalysts for biotransformation. Compared to heterotrophic hosts, cyanobacteria show unique advantages thanks to their photoautotrophic metabolism. Their ability to use light as energy and CO2 as carbon source promises a truly sustainable production platform. Their photoautotrophic metabolism offers an encouraging source of reducing power,

Continue Reading »

Intercepted dehomologation of aldoses by N-heterocyclic carbene catalysis – a novel transformation in carbohydrate chemistry

The development of an N-heterocyclic carbene (NHC) catalysed intercepted dehomologation of aldoses is reported. The unique selectivity of NHCs for aldehydes is exploited in the complex context of reducing sugars. Examples of strong substrate governance for either intercepted dehomologation or a subsequent redoxlactonisation were identified and mechanistically understood. More importantly, it was shown that catalyst

Continue Reading »

Pyrazines: Synthesis and Industrial Application of these Valuable Flavor and Fragrance Compounds

Alkyl pyrazines—other than being extracted from various natural sources such as coffee beans, cocoa beans, and vegetables—can be synthesized by chemical methods or by certain microorganisms. The importance of pyrazines for the food industry is expected to grow in the upcoming years due to the higher demand for convenience products. The roasty, nutty, and earthy

Continue Reading »
Scroll to Top